Volume 2, Issue 2 (7-2004)                   IJRM 2004, 2(2): 65-69 | Back to browse issues page

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Khademi A, Safdarian L, Alleyassin A, Agha-Hosseini M, Akbari Hamed E, Saeidi Saeidabadi H et al . The effect of L-carnitine on sperm parameters in patients candidated for Intracytoplasmic Sperm Injection. IJRM. 2004; 2 (2) :65-69
URL: http://ijrm.ssu.ac.ir/article-1-17-en.html
Abstract:   (2398 Views)
Background: The etiologic cause in near one third of male factor infertility is unknown. The percentage of men with idiopathic infertility who have been successfully treated by the empirical therapeutic modalities is not high. Objective: The aim of this study was to assay the effect of L-carnitine on sperm parameters in patients who needs intracytoplasmic sperm injection (ICSI) as a method for infertility treatment. Materials and Methods: The study population consisted of 65 men (mean age± SD: 34.4 ± 6.07) presenting with primary infertility due to idiopathic oligoasthenoteratozoospermia. L-carnitine was prescribed 1gram orally every 8 hours for 3 months. Before and after the ending of the L-carnitine treatment, semen analysis was performed. Results: The proportion of patients who had motile and grade C sperms rose significantly after treatment. Percentile of abnormal shaped sperms decreased significantly after treatment. In approximately 22%, complete asthenozoospermia changed to relative asthenozoospermia. Conclusion: Appearing motile sperms will potentially improve the technique of ICSI. The magnitude of the elevation in normal morphology is not clinically obvious, but it seems that it can be important in obtaining normal-shaped sperms for intracytoplasmic injection. Designing a study on selected patients with complete asthenozoospermia who have not other abnormalities in semen parameters can reveal the real effect of carnitine therapy in this category. Article
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1. Balercia G., Mosca F., Mantero F., Boscaro M., Mancini A., Ricciardo-Lamonica G., and Littarru G. (2004) Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril 81:93-98. [DOI:10.1016/j.fertnstert.2003.05.009] [PMID]
2. Campaniello E., Petrarolo N., Meriggiola M.C., et al. (1989) Carnitine administration in asthenospermia (Abstract). Щ International Congress of Andrology, Firenze, May 14-18.
3. Carter A.L., Stratman F.W., Huston S.M., et al. (1980) The role of carnitine and its esters in sperm metabolism. In: Frenkel R.A., McGarry J.D.(eds), Carnitine, Biosynthesis, Metabolism and Functions. Academic press, New York; 251. [DOI:10.1016/B978-0-12-267060-2.50025-0]
4. Comhaire F., Milingos S., Liapi A., Gordts S., Campo R., Depypere H., Dhont M., and Schoonjans F.(1995) The effective cumulative pregnancy rate of different modes of treatment of male infertility. Andrologia 27:217-221. [DOI:10.1111/j.1439-0272.1995.tb01096.x] [PMID]
5. Costa M., Canale D., Filicori M., D'Iddio S., and Lenzi A. (1994) L-carnitine in idiopathic asthenozoospermia, a multi center study. Andrologia 26:155-159. [DOI:10.1111/j.1439-0272.1994.tb00780.x] [PMID]
6. Dozortsev D., Rybouchkin A., De sutter P., et al. (1995) Human oocyte activation following intracytoplasmic injection: the role of sperm cell. Hum reprod 10:403-407. [DOI:10.1093/oxfordjournals.humrep.a135952] [PMID]
7. Greenberg S.H., Lipshultz L.I., Wein A.J. (1978) Experience with 425 subfertile male patients. J Urol 119:507-510. [DOI:10.1016/S0022-5347(17)57531-X]
8. Jeulin C., and Lewin L.M. (1996) Role of free L-carnitine and acetyl-L-carnitine in post-gonadal maturation of mammalian spermatozoa. Hum Reprod Update 2:87-102. [DOI:10.1093/humupd/2.2.87] [PMID]
9. Kruger T.F., Menkveld R., Stander F.S., Lombard C.J., Van Der Merwe J.P., Van Zyl J.A., et al. (1986) Sperm morphologic features as a prognostic factor in in vitro fertilization. Fertil Steril 46:1118-23. [DOI:10.1016/S0015-0282(16)49891-2]
10. Lenzi A., Lombardo F., Sgro P., Salacone P., Caponecchia L., Dondero F., and Gandini L. (2003) Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial. Fertil Steril 79:292-300. [DOI:10.1016/S0015-0282(02)04679-4]
11. Marquis N.R.P., and Fritz L.B. (1965) Effects of testosterone on the distribution of carnitine, acetyl carnitine and carnitine acetyltransferase in tissues of the reproductive system of the rat. J Biol Chem 240:2197-2200.
12. Moncada M.L., Vicari E., Cimino C., et al. (1992) Effect of acetylcarnitine treatment in oligoasthenospermic patients. Acta Eur Fertil 23:221-224.
13. Nagy Z., Liu J., Joris H., et al. (1995) The results of intracytoplasmic injection is not related to any of the three basic sperm parameters. Hum Reprod 10:1123-1129. [DOI:10.1093/oxfordjournals.humrep.a136104] [PMID]
14. Nijs M., Vanderzwalmen P., Vandamme B., et al. (1996) Fertilizing ability of immotile spermatozoa after intracytoplasmic injection. Hum Reprod 11:2180-2185. [DOI:10.1093/oxfordjournals.humrep.a019073] [PMID]
15. Palermo G., Joris H., Devroey P., and Van Steirteghem A. (1992) Pregnancies after intracytoplasmic injection of a single spermatozoa into an oocyte. Lancet 340: 17-18. [DOI:10.1016/0140-6736(92)92425-F]
16. Rowe P., Comhaire F., Hargreave T., and Mahmoud A., eds. (2000) WHO manual for the standardized investigation, diagnosis and management of the infertile male. Cambridge: Cambridge University Press:37-60.
17. Schlegel P.N., and Pavlovich C.P. (1997) Male infertility treatment options: a cost-effectiveness analysis. Journal of Clinical Outcomes Management 4:27-32.
18. Shakkaebaek N.E., Giwercman A., and De Kretser D. (1994) Pathogenesis and management of male infertility. Lancet 345:1473-1479. [DOI:10.1016/S0140-6736(94)92586-0]
19. Tournaye H. (2003) ICSI: a technique too far? Int J androl 26:63-69. [DOI:10.1046/j.1365-2605.2003.00380.x] [PMID]
20. Vicari E. and Calogero A.E. (2001) Effects of treatment with carnitines in infertile patients with prostate-vesiculo-epididymitis. Hum Reprod 16:2338-2342. [DOI:10.1093/humrep/16.11.2338] [PMID]
21. Vitali G., Parente R., and Melotti C. (1995) Carnitine supplementation in human idiopathic asthenospermia: clinical results. Drugs Exp Clin Res 21:157-159.
22. World Health Organization. (1999) WHO Laboratory manual for examination of human semen and sperm-cervical mucus interaction. 4th ed. Cambridge: Cambridge University Press.

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