Volume 20, Issue 3 (March 2022)                   IJRM 2022, 20(3): 185-194 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Le M T, Nguyen D N, Nguyen H B, Ngo V Q T, Nguyen V Q H. Ureaplasma urealyticum and Mycoplasma genitalium detection and sperm quality: A cross-sectional study in Vietnam. IJRM. 2022; 20 (3) :185-194
URL: http://ijrm.ssu.ac.ir/article-1-1983-en.html
1- Center for Reproductive Endocrinology and Infertility, Hue University Hospital, Hue University, Hue, Vietnam. Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam. , leminhtam@huemed-univ.edu.vn
2- Center for Reproductive Endocrinology and Infertility, Hue University Hospital, Hue University, Hue, Vietnam. Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
3- Department of Microbiology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
4- Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
Abstract:   (535 Views)
Background: Ureaplasma urealyticum (U. urealyticum) and Mycoplasma genitalium (M. genitalium) may colonize the male genital tract. However, the negative effects of these bacteria on overall sperm quality, including semen pH, sperm concentration, motility, morphology, and total sperm count remain unclear.
Objective: This study aimed to determine the presence of genital U. urealyticum and M. genitalium in semen and evaluate the effect of these organisms on sperm quality.
Materials and Methods: A cross-sectional study was conducted on 380 men from infertile couples at a tertiary university hospital from July 2017 to June 2018. Semen quality was analyzed according to the World Health Organization 2010 standard, and U. urealyticum and M. genitalium were detected in the semen samples using polymerase chain reaction.
Results: 338 men (88.9%) presented with at least one abnormal semen parameter. The detection rates of U. urealyticum and M. genitalium were 16.05% and 0.79%, respectively. There was no significant difference between the Ureaplasma-positive group and the Ureaplasma-negative group in terms of sperm characteristics. Sperm motility and sperm vitality in the Mycoplasma-positive group were much lower than those in the Mycoplasma-negative group (p = 0.02 and p < 0.001, respectively).

Conclusion: The presence of U. urealyticum in the semen of infertile men did not affect the sperm characteristics. Although the positive rate of M. genitalium was low, colonization by these bacteria was more likely to negatively affect sperm quality.

Full-Text [PDF 493 kb]   (310 Downloads) |   |   Full-Text (HTML)  (103 Views)  
Type of Study: Original Article | Subject: Reproductive Andrology

1. Leisegang K, Dutta S. Do lifestyle practices impede male fertility? Andrologia 2021; 53: e13595. [DOI:10.1111/and.13595] [PMCID]
2. Lafuente R, García-Blàquez N, Jacquemin B, Checa MA. Outdoor air pollution and sperm quality. Fertil Steril 2016; 106: 880-896. [DOI:10.1016/j.fertnstert.2016.08.022] [PMID]
3. Zhou YH, Ma HX, Shi XX, Liu Y. Ureaplasma spp. in male infertility and its relationship with semen quality and seminal plasma components. J Microbiol Immunol Infect 2018; 51: 778-783. [DOI:10.1016/j.jmii.2016.09.004] [PMID]
4. Gdoura R, Kchaou W, Chaari Ch, Znazen A, Keskes L, Rebai T, et al. Ureaplasma urealyticum, ureaplasma parvum, mycoplasma hominis and mycoplasma genitalium infections and semen quality of infertile men. BMC Infect Dis 2007; 7: 129. [DOI:10.1186/1471-2334-7-129] [PMID] [PMCID]
5. Beeton ML, Payne MS, Jones L. The role of Ureaplasma spp. in the development of nongonococcal urethritis and infertility among men. Clin Microbiol Rev 2019; 32: e00137. [DOI:10.1128/CMR.00137-18] [PMID] [PMCID]
6. Yoshida T, Maeda ShI, Deguchi T, Ishiko H. Phylogeny-based rapid identification of mycoplasmas and ureaplasmas from urethritis patients. J Clin Microbiol 2002; 40: 105-110. [DOI:10.1128/JCM.40.1.105-110.2002] [PMID] [PMCID]
7. Reichart M, Levi H, Kahane I, Bartoov B. Dual energy metabolism-dependent effect of Ureaplasma urealyticum infection on sperm activity. J Androl 2001; 22: 404-412.
8. Pergialiotis V, Karampetsou N, Perrea DN, Konstantopoulos P, Daskalakis G. The impact of bacteriospermia on semen parameters: A meta-analysis. J Family Reprod Health 2018; 12: 73-83.
9. Al-Sweih NA, Al-Fadli AH, Omu AE, Rotimi VO. Prevalence of chlamydia trachomatis, mycoplasma hominis, mycoplasma genitalium, and ureaplasma urealyticum infections and seminal quality in infertile and fertile men in Kuwait. J Androl 2012; 33: 1323-1329. [DOI:10.2164/jandrol.111.013821] [PMID]
10. World Health Organization. WHO Laboratory manual for the examination and processing of human semen. 5th ed. Geneva: World Health Organization Press; 2010.
11. Zinzendorf NY, Kouassi-Agbessi BT, Lathro JS, Don C, Kouadio L, Loukou YG. Ureaplasma urealyticum or mycoplasma hominis infections and semen quality of infertile men in Abidjan. J Reprod Contracept 2008; 19: 65-72. [DOI:10.1016/S1001-7844(08)60008-5]
12. Riley DE, Samadpour M, Krieger JN. Detection of variable DNA repeats in diverse eukaryotic microorganisms by a single set of polymerase chain reaction primers. J Clin Microbiol 1991; 29: 2746-2751. [DOI:10.1128/jcm.29.12.2746-2751.1991] [PMID] [PMCID]
13. Huang Ch, Long X, Jing Sh, Fan L, Xu K, Wang S, et al. Ureaplasma urealyticum and mycoplasma hominis infections and semen quality in 19,098 infertile men in China. World J Urol 2016; 34: 1039-1044. [DOI:10.1007/s00345-015-1724-z] [PMID]
14. Moridi Kh, Hemmaty M, Azimian A, Fallah MH, Khaneghahi Abyaneh H, Ghazvini K. Epidemiology of genital infections caused by Mycoplasma hominis, m. genitalium and ureaplasma urealyticum in Iran: A systematic review and meta-analysis study (2000-2019). BMC Public Health 2020; 20: 1020. [DOI:10.1186/s12889-020-08962-5] [PMID] [PMCID]
15. Wang Y, Liang CL, Wu JQ, Xu Ch, Qin ShX, Gao ESh. Do ureaplasma urealyticum infections in the genital tract affect semen quality? Asian J Androl 2006; 8: 562-568. [DOI:10.1111/j.1745-7262.2006.00190.x] [PMID]
16. Lee JSh, Kim KT, Lee HS, Yang KM, Seo JT, Choe JH. Concordance of ureaplasma urealyticum and mycoplasma hominis in infertile couples: Impact on semen parameters. Urology 2013; 81: 1219-1224. [DOI:10.1016/j.urology.2013.02.044] [PMID]
17. Le MT, Nguyen TLN, Le DD, Ngo TVQ, Nguyen ATC, Nguyen BH, et al. Is genital tract infection related to tubal diseases in infertile Vietnamese women? J Infect Dev Ctries 2019; 13: 906-913. [DOI:10.3855/jidc.11632] [PMID]
18. Lan PT, Lundborg CS, Phuc HD, Sihavong A, Unemo M, Chuc NTK, et al. Reproductive tract infections including sexually transmitted infections: A population-based study of women of reproductive age in a rural district of Vietnam. Sex Transm Infect 2008; 84: 126-132. [DOI:10.1136/sti.2007.027821] [PMID]
19. Huang C, Zhu HL, Xu KR, Wang SY, Fan LQ, Zhu WB. Mycoplasma and ureaplasma infection and male infertility: A systematic review and meta-analysis. Andrology 2015; 3: 809-816. [DOI:10.1111/andr.12078] [PMID]
20. Liu J, Wang Q, Ji X, Guo Sh, Dai Y, Zhang Zh, et al. Prevalence of ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis infections, and semen quality in infertile and fertile men in China. Urology 2014; 83: 795-799. [DOI:10.1016/j.urology.2013.11.009] [PMID]
21. Veiga E, Treviño M, Romay AB, Navarro D, Trastoy R, Macía M. Colonisation of the male reproductive tract in asymptomatic infertile men: Effects on semen quality. Andrologia 2020; 52: e13637. [DOI:10.1111/and.13637] [PMID]
22. Gallegos G, Ramos B, Santiso R, Goyanes V, Gosálvez J, Fernández JL. Sperm DNA fragmentation in infertile men with genitourinary infection by chlamydia trachomatis and mycoplasma. Fertil Steril 2008; 90: 328-334. [DOI:10.1016/j.fertnstert.2007.06.035] [PMID]

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb